{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:23:37Z","timestamp":1791217417452,"version":"4.1.0"},"reference-count":27,"publisher":"National Academy of Sciences","issue":"48","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,11,26]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    STAR syndrome is an X-linked dominant developmental disorder caused by mutations in\n                    <jats:italic>FAM58A<\/jats:italic>\n                    , which codes for an orphan cyclin with undescribed functions. Here we demonstrate that cyclin M interacts with CDK10 (one of the last orphan CDKs) to form a novel cyclin-dependent kinase. CDK10 is known to be involved in the control of cell division and in the resistance of certain breast cancers to endocrine therapy. We show that CDK10\/cyclin M phosphorylates and positively regulates the degradation of ETS2, a transcription factor that plays key roles in cancer and development. These results shed light on the molecular mechanisms underlying STAR syndrome, and they pave the way for the exploration of the functions of the CDK10\/cyclin M kinase.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1306814110","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T23:48:45Z","timestamp":1384213725000},"page":"19525-19530","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":85,"title":["CDK10\/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome"],"prefix":"10.1073","volume":"110","author":[{"given":"Vincent J.","family":"Guen","sequence":"first","affiliation":[{"name":"P2I2 Group, Protein Phosphorylation and Human Disease Unit, Station Biologique, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 de Service et de Recherche USR3151, 29680 Roscoff, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Gamble","sequence":"additional","affiliation":[{"name":"P2I2 Group, Protein Phosphorylation and Human Disease Unit, Station Biologique, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 de Service et de Recherche USR3151, 29680 Roscoff, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Flajolet","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Unger","sequence":"additional","affiliation":[{"name":"Service of Medical Genetics and Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Thollet","sequence":"additional","affiliation":[{"name":"Institut des Sciences Pharmaceutiques et Biologiques (ISPB), Facult\u00e9 de Pharmacie, Universit\u00e9 Lyon 1, 69000 Lyon, France; and"},{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1052, CNRS Unit\u00e9 Mixte de Recherche 5286, 69000 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoan","family":"Ferandin","sequence":"additional","affiliation":[{"name":"P2I2 Group, Protein Phosphorylation and Human Disease Unit, Station Biologique, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 de Service et de Recherche USR3151, 29680 Roscoff, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Superti-Furga","sequence":"additional","affiliation":[{"name":"Service of Medical Genetics and Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Institut des Sciences Pharmaceutiques et Biologiques (ISPB), Facult\u00e9 de Pharmacie, Universit\u00e9 Lyon 1, 69000 Lyon, France; and"},{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1052, CNRS Unit\u00e9 Mixte de Recherche 5286, 69000 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Meijer","sequence":"additional","affiliation":[{"name":"P2I2 Group, Protein Phosphorylation and Human Disease Unit, Station Biologique, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 de Service et de Recherche USR3151, 29680 Roscoff, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Colas","sequence":"additional","affiliation":[{"name":"P2I2 Group, Protein Phosphorylation and Human Disease Unit, Station Biologique, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 de Service et de Recherche USR3151, 29680 Roscoff, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2602"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1109-1275"},{"key":"e_1_3_3_3_2","first-page":"2097","article-title":"PISSLRE, a human novel CDC2-related protein kinase","volume":"9","author":"Gra\u00f1a X","year":"1994","unstructured":"X Gra\u00f1a, PP Claudio, A De Luca, N Sang, A Giordano, PISSLRE, a human novel CDC2-related protein kinase. Oncogene 9, 2097\u20132103 (1994).","journal-title":"Oncogene"},{"key":"e_1_3_3_4_2","first-page":"3037","article-title":"Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine\/threonine kinases","volume":"9","author":"Brambilla R","year":"1994","unstructured":"R Brambilla, G Draetta, Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine\/threonine kinases. Oncogene 9, 3037\u20133041 (1994).","journal-title":"Oncogene"},{"key":"e_1_3_3_5_2","first-page":"3992","article-title":"The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle","volume":"55","author":"Li S","year":"1995","unstructured":"S Li, et al., The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle. Cancer Res 55, 3992\u20133995 (1995).","journal-title":"Cancer Res"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.01.001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2011.1617"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.01.022"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204295"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.86"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35057033"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266103"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1768"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.11.019"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708188200"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5676"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3395"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.548"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204129"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1028"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.019"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204037"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05236.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/379534a0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/451021a"},{"key":"e_1_3_3_26_2","first-page":"389","article-title":"STAR syndrome and nephroblastoma-FAM58A linking organogenesis and tumorigenesis?","volume":"169","author":"Rakenius A","year":"2010","unstructured":"A Rakenius, et al., STAR syndrome and nephroblastoma-FAM58A linking organogenesis and tumorigenesis? Eur J Pediatr 169, 389 (2010).","journal-title":"Eur J Pediatr"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.32"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1306814110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T21:35:25Z","timestamp":1649799325000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1306814110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,11]]},"references-count":27,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2013,11,26]]}},"alternative-id":["10.1073\/pnas.1306814110"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1306814110","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,11]]},"assertion":[{"value":"2013-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}