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The recovery of heart function after ischemia was improved following inhibition of red blood cell arginase. This effect depended on the specific protein producing nitric oxide. The results demonstrate an important function by red blood cells in regulating heart function during ischemia via nitric oxide production under tight control by arginase.<\/jats:p>","DOI":"10.1073\/pnas.1307058110","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T22:24:39Z","timestamp":1377555879000},"page":"15049-15054","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":144,"title":["Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity"],"prefix":"10.1073","volume":"110","author":[{"given":"Jiangning","family":"Yang","sequence":"first","affiliation":[{"name":"Divison of Cardiology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian T.","family":"Gonon","sequence":"additional","affiliation":[{"name":"Divison of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Ove","family":"Sj\u00f6quist","sequence":"additional","affiliation":[{"name":"Divison of Cardiology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon O.","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pernow","sequence":"additional","affiliation":[{"name":"Divison of Cardiology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,8,26]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292706"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22493"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.02.136"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402927101"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/380221a0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407490102"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0503-496"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm954"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-442277"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2000.106805"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-3992"},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","unstructured":"Ulker P Gunduz F Meiselman HJ Baskurt OK (October 17 2012) Nitric oxide generated by red blood cells following exposure to shear stress dilates isolated small mesenteric arteries under hypoxic conditions. 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