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Alternative, safe strategies of impeding postnatal HIV-1 transmission will be required to eliminate infant HIV-1 infection. In this paper, we identify an innate HIV-neutralizing protein in breast milk, Tenascin-C, which captures and neutralizes HIV-1 virions via binding to the chemokine coreceptor binding site on the HIV-1 Envelope. This protein has the potential to be developed as a prevention strategy for postnatal and other modes of HIV-1 transmission.<\/jats:p>","DOI":"10.1073\/pnas.1307336110","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T22:57:55Z","timestamp":1382396275000},"page":"18220-18225","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":77,"title":["Tenascin-C is an innate broad-spectrum, HIV-1\u2013neutralizing protein in breast milk"],"prefix":"10.1073","volume":"110","author":[{"given":"Genevieve G.","family":"Fouda","sequence":"first","affiliation":[{"name":"Human Vaccine Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick H.","family":"Jaeger","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Amos","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Ho","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika L.","family":"Kunz","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Anasti","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa W.","family":"Stamper","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke E.","family":"Liebl","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly H.","family":"Barbas","sequence":"additional","affiliation":[{"name":"Lactation Support Program, Children\u2019s Hospital Boston, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Cell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Arthur","family":"Moseley","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences and Policy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Xin","family":"Liao","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold P.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Department of Cell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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