{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:06:51Z","timestamp":1792667211075,"version":"4.5.0"},"reference-count":21,"publisher":"National Academy of Sciences","issue":"24","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,6,11]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Wolf\u2013Hirschhorn syndrome (WHS), caused by deletions in 4p16.3, was the first recognized subtelomeric deletion syndrome. As with other syndromes of this class, WHS has not yet been subjected to an intensive, systematic analysis using mouse or cellular models. We recently identified leucine zipper-EF-hand containing transmembrane protein 1 (Letm1) as a mitochondrial Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/H\n                    <jats:sup>+<\/jats:sup>\n                    antiporter, located in the core WHS region. In this study,\n                    <jats:italic>Letm1<\/jats:italic>\n                    null mice were generated and characterized. Deletion of\n                    <jats:italic>Letm1<\/jats:italic>\n                    disrupts early embryonic development, reduces glucose oxidation and thus particularly affects brain function.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1308558110","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T01:46:29Z","timestamp":1369791989000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":122,"title":["Letm1, the mitochondrial Ca\n                    <sup>2+<\/sup>\n                    \/H\n                    <sup>+<\/sup>\n                    antiporter, is essential for normal glucose metabolism and alters brain function in Wolf\u2013Hirschhorn syndrome"],"prefix":"10.1073","volume":"110","author":[{"given":"Dawei","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Howard Hughes Medical Institute,"},{"name":"Manton Center for Orphan Disease, Children\u2019s Hospital Boston, and"},{"name":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Howard Hughes Medical Institute,"},{"name":"Manton Center for Orphan Disease, Children\u2019s Hospital Boston, and"},{"name":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clary B.","family":"Clish","sequence":"additional","affiliation":[{"name":"Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Clapham","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Howard Hughes Medical Institute,"},{"name":"Manton Center for Orphan Disease, Children\u2019s Hospital Boston, and"},{"name":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.01.005"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.05.011"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00046.2007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2005.06.011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2005"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02246"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10230"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10234"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1127"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.03.071"},{"key":"e_1_3_3_11_2","first-page":"22","article-title":"Calcium transport across the inner mitochondrial membrane: Molecular mechanisms and pharmacology","volume":"22","author":"Csordas G","year":"2011","unstructured":"G Csordas, P Varnai, T Golenar, SS Sheu, G Hajnoczky, Calcium transport across the inner mitochondrial membrane: Molecular mechanisms and pharmacology. 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