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In particular, by using platelets harvested from hyperhomocysteinemic patients, H\n                    <jats:sub>2<\/jats:sub>\n                    S generated within the platelets in turn activates the arachidonic acid cascade by phosphorylating phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    . This cascade of events primes the platelet that becomes more responsive (reactive) to endogenous stimuli. Finally, our study also suggests that H\n                    <jats:sub>2<\/jats:sub>\n                    S could represent a unique biomarker in patients affected with hyperhomocystinemia to define the susceptibility of a cardiovascular event driven by platelets.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1309049110","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T22:31:16Z","timestamp":1378765876000},"page":"15812-15817","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":57,"title":["Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia"],"prefix":"10.1073","volume":"110","author":[{"given":"Roberta","family":"d\u2019Emmanuele di Villa Bianca","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Mitidieri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo N. 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