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Previous studies on G protein-coupled receptor kinase-interactor 2 (GIT2) have suggested that it regulates thymocyte positive selection, neutrophil-direction sensing, and cell motility during immune responses by regulating the activity of the small GTPases ADP ribosylation factors and Ras-related C3 botulinum toxin substrate 1. Here, we show that GIT2 protects against severe colitis in mice by inhibiting the ubiquitination of TNF receptor associated factor 6 and negatively regulating Toll-like receptor (TLR) signaling. GIT2 is essential for the resolution of TLR signaling, and the deficiency of\n                    <jats:italic>Git2<\/jats:italic>\n                    leads to uncontrolled inflammation and severe immune diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1309218111","type":"journal-article","created":{"date-parts":[[2014,5,30]],"date-time":"2014-05-30T23:51:43Z","timestamp":1401493903000},"page":"8883-8888","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":31,"title":["The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling"],"prefix":"10.1073","volume":"111","author":[{"given":"Juncheng","family":"Wei","sequence":"first","affiliation":[{"name":"Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China;"},{"name":"Beijing Institute of Radiation Medicine, Beijing 100850, China;"},{"name":"State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Engineering Research Center for Protein Drugs, Beijing 102206, China; 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