{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:35:13Z","timestamp":1781109313982,"version":"3.54.1"},"reference-count":30,"publisher":"National Academy of Sciences","issue":"36","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,9,3]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Torso-like (Tsl) is the sole\n                    <jats:italic>Drosophila<\/jats:italic>\n                    member of the membrane attack complex\/perforin-like protein superfamily, generally known for pore-forming function and immune defence roles. Tsl, however, has a well-characterized developmental role in controlling activation of the receptor tyrosine kinase Torso (Tor) to achieve patterning of the termini of the early embryo. Here we report that the second known role of Tor, as the receptor for the hormone that induces metamorphosis, does not require Tsl. Instead, we find that Tsl controls developmental timing and growth independently of Tor. We conclude that Tsl plays a broader than expected role during development and is not merely a specialized cue for Tor signaling.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1309780110","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T21:59:24Z","timestamp":1376949564000},"page":"14688-14692","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":53,"title":["Torso-like functions independently of Torso to regulate\n                    <i>Drosophila<\/i>\n                    growth and developmental timing"],"prefix":"10.1073","volume":"110","author":[{"given":"Travis K.","family":"Johnson","sequence":"first","affiliation":[{"name":"School of Biological Sciences,"},{"name":"Department of Biochemistry and Molecular Biology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tova","family":"Crossman","sequence":"additional","affiliation":[{"name":"School of Biological 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(2002) Systematic determination of patterns of gene expression during Drosophila embryogenesis. 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