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Treatment with drugs known to cause hemolytic anemia in humans do not cause damage to the mouse RBCs nor to the transfused normal human RBCs; but a robust hemolytic response is observed in the mice transfused with G6PD-deficient human RBCs. The immediate impact of this model will be in advancing the development antimalarial drugs.<\/jats:p>","DOI":"10.1073\/pnas.1310402110","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T23:17:51Z","timestamp":1381187871000},"page":"17486-17491","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":43,"title":["Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity"],"prefix":"10.1073","volume":"110","author":[{"given":"Rosemary","family":"Rochford","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Upstate Medical University, Syracuse, NY 13210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Ohrt","sequence":"additional","affiliation":[{"name":"Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Baresel","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Upstate Medical University, Syracuse, NY 13210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Campo","sequence":"additional","affiliation":[{"name":"Medicines for Malaria Venture, 1215 Geneva, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Sampath","sequence":"additional","affiliation":[{"name":"Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Magill","sequence":"additional","affiliation":[{"name":"Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu L.","family":"Tekwani","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research and"},{"name":"Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry A.","family":"Walker","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research and"},{"name":"Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,10,7]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2008.12.005"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.779"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/424663"},{"key":"e_1_3_3_4_2","volume-title":"Anti-malarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery","author":"Brueckner RP","year":"2001","unstructured":"RP Brueckner, C Ohrt, JK Baird, WK Milhous, 8-Aminoquinolines. 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