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Using resting-state functional brain connectivity in adolescents, we show that maltreatment predicts lower prefrontal\u2013hippocampal connectivity in females and males but lower prefrontal\u2013amygdala connectivity only in females. Altered connectivity, in turn, mediated the development of internalizing symptoms. These results highlight the importance of fronto\u2013hippocampal connectivity for both sexes in internalizing symptoms following maltreatment. The additional impact on fronto\u2013amygdala connectivity in females may help explain their higher risk for anxiety and depression.<\/jats:p>","DOI":"10.1073\/pnas.1310766110","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T20:58:48Z","timestamp":1383598728000},"page":"19119-19124","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":372,"title":["Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence"],"prefix":"10.1073","volume":"110","author":[{"given":"Ryan J.","family":"Herringa","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53719;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus M.","family":"Birn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53719;"},{"name":"Department of Medical Physics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula L.","family":"Ruttle","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53719;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory A.","family":"Burghy","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Wisconsin\u2013Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane E.","family":"Stodola","sequence":"additional","affiliation":[{"name":"Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin\u2013Madison, Madison, WI 53705; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53719;"},{"name":"Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin\u2013Madison, Madison, WI 53705; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn J.","family":"Essex","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53719;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,11,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61706-7"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291706009640"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-005-0624-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.186"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2010.05.017"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","unstructured":"Murray CJL et al. 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