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We observed that infection with a virulent PRV strain induces synchronous and cyclical neural activity, but this activity disappears during infection with a vaccine strain that does not cause mad itch. We demonstrate the aberrant activity depends on a viral fusion protein, and its trafficking specifically into axons. These findings correlate the disrupted physiology to the known neuropathy in vivo.<\/jats:p>","DOI":"10.1073\/pnas.1311062110","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T22:24:39Z","timestamp":1377555879000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":32,"title":["In vivo imaging of alphaherpesvirus infection reveals synchronized activity dependent on axonal sorting of viral proteins"],"prefix":"10.1073","volume":"110","author":[{"given":"Andrea E.","family":"Granstedt","sequence":"first","affiliation":[{"name":"Department of Molecular Biology,"},{"name":"Princeton Neuroscience Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens B.","family":"Bosse","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology,"},{"name":"Princeton Neuroscience Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan Y.","family":"Thiberge","sequence":"additional","affiliation":[{"name":"Princeton Neuroscience Institute, and"},{"name":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn W.","family":"Enquist","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology,"},{"name":"Princeton Neuroscience Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,8,26]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"2773","volume-title":"Fields Virology","author":"Cohen JI","year":"2007","unstructured":"JI Cohen, SE Straus, AM Arvin, Varicella-zoster virus replication, pathogenesis, and management. 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