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Reducing the levels of the demethylase\n                    <jats:italic>SMCX\/Jarid1c<\/jats:italic>\n                    in primary neurons reversed down-regulation of key neuronal genes caused by mutant Huntingtin expression and was neuroprotective in a\n                    <jats:italic>Drosophila<\/jats:italic>\n                    HD model. These results suggest that targeting epigenetic signatures may be an effective strategy to ameliorate the consequences of HD and other neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1311323110","type":"journal-article","created":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T01:56:52Z","timestamp":1374285412000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":172,"title":["Targeting H3K4 trimethylation in Huntington disease"],"prefix":"10.1073","volume":"110","author":[{"given":"Malini","family":"Vashishtha","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Human Behavior and UCI Institute of Memory Impairments and Neurological Disorders,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferah","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa A.","family":"Gipson","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Kratter","sequence":"additional","affiliation":[{"name":"Gladstone Institute of Neurological Disease Biomedical Sciences Graduate Program and Medical Scientist Training Program and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Bodai","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology and Developmental Biology Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology and Developmental Biology Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior and UCI Institute of Memory Impairments and Neurological Disorders,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Labadorf","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Vogel-Ciernia","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior, University of California, Irvine, CA 92697;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Troncosco","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Neurology, and Neuroscience and Neuropathology, Johns Hopkins University, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Neurology, and Neuroscience and Neuropathology, Johns Hopkins University, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian P.","family":"Bates","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics, King's College, London SE1 9RT, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Krainc","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazaleh","family":"Sadri-Vakili","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Finkbeiner","sequence":"additional","affiliation":[{"name":"Gladstone Institute of Neurological Disease Taube-Koret Center for Huntington\u2019s Disease Research, Departments of Neurology and Physiology, University of California, San Francisco, CA 94158;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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