{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:45:04Z","timestamp":1791308704187,"version":"4.3.1"},"reference-count":24,"publisher":"National Academy of Sciences","issue":"46","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,11,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Viroporins are small, hydrophobic viral proteins that form pores on host cell membranes, and their expression can increase the production of progeny virus particles. Recently, we have shown that human JC polyomavirus agnoprotein acts as a viroporin. We have investigated the role of host cellular proteins in the viroporin activity of the agnoprotein. We demonstrated that an interaction of the agnoprotein with the \u03b4 subunit of AP-3 prevents AP-3\u2013mediated vesicular trafficking and blocks the targeted transport of the agnoprotein for lysosomal degradation. These findings demonstrate a previously undescribed paradigm in virus\u2013host interactions regulating virus replication and suggest that viroporins of other viruses may also be regulated by specific interactions with host cellular proteins.<\/jats:p>","DOI":"10.1073\/pnas.1311457110","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T23:37:12Z","timestamp":1383003432000},"page":"18668-18673","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":42,"title":["Viroporin activity of the JC polyomavirus is regulated by interactions with the adaptor protein complex 3"],"prefix":"10.1073","volume":"110","author":[{"given":"Tadaki","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan;"},{"name":"Department of Pathology, National Institute of Infectious Diseases, Musashimurayama 208-0011, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Orba","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Makino","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Okada","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cellular Pathology, Hokkaido University School of Medicine, Sapporo 060-8638, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Sunden","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine, Sapporo 060-0818, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Institute of Infectious Diseases, Musashimurayama 208-0011, Japan;"},{"name":"Global Virus Network, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Hall","sequence":"additional","affiliation":[{"name":"Global Virus Network, Baltimore, MD 21201;"},{"name":"Centre for Research in Infectious Diseases, University College Dublin, Dublin 4, Ireland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Sawa","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan;"},{"name":"Global Virus Network, Baltimore, MD 21201;"},{"name":"Global Centers of Excellence Program for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,10,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12128"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05031-11"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000801"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2820"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.122895"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00780-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205393200"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207847200"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1031527100"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403663200"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.09.033"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002857"},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","unstructured":"JM Hyser MR Collinson-Pautz B Utama MK Estes Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity. mBio 1(5):e00265-10. 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