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To test this hypothesis, we have serially passaged\n                    <jats:italic>Leishmania donovani<\/jats:italic>\n                    in mice receiving arsenic in drinking water at environmentally relevant levels. In support of this hypothesis, we show that after five monthly passages,\n                    <jats:italic>Leishmania<\/jats:italic>\n                    parasites become stably resistant to Pentostam in vitro and in vivo.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1311535110","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T23:37:12Z","timestamp":1383003432000},"page":"19932-19937","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":61,"title":["Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis"],"prefix":"10.1073","volume":"110","author":[{"given":"Meghan R.","family":"Perry","sequence":"first","affiliation":[{"name":"Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Wyllie","sequence":"additional","affiliation":[{"name":"Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Raab","sequence":"additional","affiliation":[{"name":"College of Physical Sciences\u2013Chemistry, Trace Element Speciation Laboratory, University of Aberdeen, Aberdeen AB24 3UE, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Feldmann","sequence":"additional","affiliation":[{"name":"College of Physical Sciences\u2013Chemistry, Trace Element Speciation Laboratory, University of Aberdeen, Aberdeen AB24 3UE, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan H.","family":"Fairlamb","sequence":"additional","affiliation":[{"name":"Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,10,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10178-2"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00347-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1748"},{"key":"e_1_3_3_4_2","first-page":"331","article-title":"Visceral leishmaniasis (kala-azar): Challenges ahead","volume":"123","author":"Singh RK","year":"2006","unstructured":"RK Singh, HP Pandey, S Sundar, Visceral leishmaniasis (kala-azar): Challenges ahead. 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