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Thus, we hypothesize that endothelial cells stimulate organ and tissue regeneration via production of bioactive EETs. To determine whether endothelial-derived EETs affect physiologic tissue growth in vivo, we used genetic and pharmacological tools to manipulate endogenous EET levels. We show that endothelial-derived EETs play a critical role in accelerating tissue growth in vivo, including liver regeneration, kidney compensatory growth, lung compensatory growth, wound healing, corneal neovascularization, and retinal vascularization. Administration of synthetic EETs recapitulated these results, whereas lowering EET levels, either genetically or pharmacologically, delayed tissue regeneration, demonstrating that pharmacological modulation of EETs can affect normal organ and tissue growth. We also show that soluble epoxide hydrolase inhibitors, which elevate endogenous EET levels, promote liver and lung regeneration. Thus, our observations indicate a central role for EETs in organ and tissue regeneration and their contribution to tissue homeostasis.<\/jats:p>","DOI":"10.1073\/pnas.1311565110","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:11:18Z","timestamp":1375143078000},"page":"13528-13533","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":138,"title":["Epoxyeicosanoids promote organ and tissue regeneration"],"prefix":"10.1073","volume":"110","author":[{"given":"Dipak","family":"Panigrahy","sequence":"first","affiliation":[{"name":"Vascular Biology Program and"},{"name":"Division of Pediatric Oncology, Dana\u2013Farber Cancer Institute, Harvard Medical School, Boston, MA 02115;"},{"name":"Center for Vascular Biology Research,"},{"name":"Department of Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian 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