{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:04:34Z","timestamp":1792069474372,"version":"4.4.0"},"reference-count":32,"publisher":"National Academy of Sciences","issue":"42","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,10,15]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    We discovered that SAMP1\/YitFc (SAMP) mice, which develop spontaneous Crohn\u2019s disease (CD)-like ileitis in the absence of nucleotide-binding oligomerization domain-containing 2 (\n                    <jats:italic>NOD2<\/jats:italic>\n                    ) genetic mutations, fail to respond to muramyl dipeptide and display impaired bacterial clearance. These results support the concept that a dysregulated NOD2 in SAMP mice predisposes them to chronic intestinal inflammation. We believe that our study provides a paradigm shift by demonstrating that CD-like ileitis is caused by an innate immune defect, rather than an overly aggressive adaptive immune response. Therefore, preventive and curative treatments for CD should be directed to boost, rather than suppress, mucosal innate immune responses.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1311657110","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T02:09:28Z","timestamp":1380593368000},"page":"16999-17004","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["Dysregulated NOD2 predisposes SAMP1\/YitFc mice to chronic intestinal inflammation"],"prefix":"10.1073","volume":"110","author":[{"given":"Daniele","family":"Corridoni","sequence":"first","affiliation":[{"name":"Departments of aMedicine and"},{"name":"Digestive Health Research Center, Case Western Reserve University, Cleveland, OH 44122;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Kodani","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"},{"name":"Digestive Health Research Center, Case Western Reserve University, Cleveland, OH 44122;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rodriguez-Palacios","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"},{"name":"Digestive Health Research Center, Case Western Reserve University, Cleveland, OH 44122;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa T.","family":"Pizarro","sequence":"additional","affiliation":[{"name":"Pathology, and"},{"name":"Digestive Health Research Center, Case Western Reserve University, Cleveland, OH 44122;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xin","sequence":"additional","affiliation":[{"name":"Pathology, and"},{"name":"Digestive Health Research Center, Case Western Reserve University, Cleveland, OH 44122;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourtney P.","family":"Nickerson","sequence":"additional","affiliation":[{"name":"Digestive Health Research Center, Case Western Reserve University, Cleveland, OH 44122;"},{"name":"Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"McDonald","sequence":"additional","affiliation":[{"name":"Digestive Health Research Center, Case Western Reserve University, Cleveland, OH 44122;"},{"name":"Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus F.","family":"Ley","sequence":"additional","affiliation":[{"name":"Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek W.","family":"Abbott","sequence":"additional","affiliation":[{"name":"Pathology, and"},{"name":"Digestive Health Research Center, Case Western Reserve University, Cleveland, OH 44122;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Cominelli","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"},{"name":"Pathology, and"},{"name":"Digestive Health Research Center, Case Western Reserve University, Cleveland, OH 44122;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,9,30]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206473200"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200651200"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200673200"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1086"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704746200"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.4.2380"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102214"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2069"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","unstructured":"Homer CR Richmond AL Rebert NA Achkar JP McDonald C (2010) ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis. 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