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At the cerebellar synapse between parallel fiber (PF) and Purkinje cell (PC), postsynaptic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling is not the result of ionotropic glutamatergic receptor activation, while T-type Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.1 channels are abundantly expressed in PCs. We show that they are required for long-term potentiation but not for long-term depression at PF\u2013PC synapses. Because plasticity at this site has long been proposed to be important for cerebellar forms of motor learning, we have checked the behavioral incidence of acute or chronic blockade of T-type channels. In this condition, we show impairment of demanding cerebellar motor learning tasks.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1311686110","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:14:48Z","timestamp":1385424888000},"page":"20302-20307","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":77,"title":["T-type channel blockade impairs long-term potentiation at the parallel fiber\u2013Purkinje cell synapse and cerebellar learning"],"prefix":"10.1073","volume":"110","author":[{"given":"Romain","family":"Ly","sequence":"first","affiliation":[{"name":"Institut de Biologie de l\u2019Ecole Normale Sup\u00e9rieure, IBENS, F-75005 Paris, France;"},{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 8197, F-75005 Paris, France;"},{"name":"\u00c9cole Normale Sup\u00e9rieure, F-75005 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Institut de Biologie de l\u2019Ecole Normale Sup\u00e9rieure, IBENS, F-75005 Paris, France;"},{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 8197, F-75005 Paris, France;"},{"name":"\u00c9cole Normale Sup\u00e9rieure, F-75005 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"Schonewille","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, ErasmusMC, 3015 GE, Rotterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Arabo","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche des Sciences et Techniques, Universit\u00e9 de Rouen, 76821 Mont Saint Aignan Cedex, France;"},{"name":"Universit\u00e9 Pierre et Marie Curie Univ Paris 6, F-75005 Paris, France;"},{"name":"CNRS, UMR 7102, F-75005 Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Rondi-Reig","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie Univ Paris 6, F-75005 Paris, France;"},{"name":"CNRS, UMR 7102, F-75005 Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"L\u00e9na","sequence":"additional","affiliation":[{"name":"Institut de Biologie de l\u2019Ecole Normale Sup\u00e9rieure, IBENS, F-75005 Paris, France;"},{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 8197, F-75005 Paris, France;"},{"name":"\u00c9cole Normale Sup\u00e9rieure, F-75005 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Casado","sequence":"additional","affiliation":[{"name":"Institut de Biologie de l\u2019Ecole Normale Sup\u00e9rieure, IBENS, F-75005 Paris, France;"},{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 8197, F-75005 Paris, France;"},{"name":"\u00c9cole Normale Sup\u00e9rieure, F-75005 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris I.","family":"De Zeeuw","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, ErasmusMC, 3015 GE, Rotterdam, The Netherlands;"},{"name":"Netherlands Institute for Neuroscience, 1105 BA, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Feltz","sequence":"additional","affiliation":[{"name":"Institut de Biologie de l\u2019Ecole Normale Sup\u00e9rieure, IBENS, F-75005 Paris, France;"},{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 8197, F-75005 Paris, France;"},{"name":"\u00c9cole Normale Sup\u00e9rieure, F-75005 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,11,25]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.07.009"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00562-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3312"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.5.1901"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.077bo.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013358"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-10-06403.1995"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2921-12.2013"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-06-01895.1999"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.074211"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0362-09.2009"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2939-06.2006"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02442"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2013.00095"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.10.031"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014103"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016881"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/25541"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/81792"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122206399"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm800419w"},{"key":"e_1_3_3_22_2","unstructured":"Ly R et al. 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