{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:45:50Z","timestamp":1791287150437,"version":"4.1.0"},"reference-count":55,"publisher":"National Academy of Sciences","issue":"32","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,8,6]]},"abstract":"<jats:p>\n                    Celiac disease is an intestinal autoimmune disease driven by dietary gluten and gluten-specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    T-cell responses. In celiac patients on a gluten-free diet, exposure to gluten induces the appearance of gluten-specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells with gut-homing potential in the peripheral blood. Here we show that gluten exposure also induces the appearance of activated, gut-homing CD8\n                    <jats:sup>+<\/jats:sup>\n                    \u03b1\u03b2 and \u03b3\u03b4 T cells in the peripheral blood. Single-cell T-cell receptor sequence analysis indicates that both of these cell populations have highly focused T-cell receptor repertoires, indicating that their induction is antigen-driven. These results reveal a previously unappreciated role of antigen in the induction of CD8\n                    <jats:sup>+<\/jats:sup>\n                    \u03b1\u03b2 and \u03b3\u03b4 T cells in celiac disease and demonstrate a coordinated response by all three of the major types of T cells. More broadly, these responses may parallel adaptive immune responses to viral pathogens and other systemic autoimmune diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1311861110","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T23:53:19Z","timestamp":1374537199000},"page":"13073-13078","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":189,"title":["Dietary gluten triggers concomitant activation of CD4\n                    <sup>+<\/sup>\n                    and CD8\n                    <sup>+<\/sup>\n                    \u03b1\u03b2 T cells and \u03b3\u03b4 T cells in celiac disease"],"prefix":"10.1073","volume":"110","author":[{"given":"Arnold","family":"Han","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine,"},{"name":"Department of Microbiology and Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan W.","family":"Newell","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, and"},{"name":"Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Glanville","sequence":"additional","affiliation":[{"name":"Institute for Immunity, Transplantation and Infection,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nielsen","family":"Fernandez-Becker","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitan","family":"Khosla","sequence":"additional","affiliation":[{"name":"Departments of eChemistry and"},{"name":"Chemical Engineering, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-hsiu","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Microbiology 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