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U.S.A."],"published-print":{"date-parts":[[2013,8,6]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:italic>T<\/jats:italic>\n                    ransient\n                    <jats:italic>R<\/jats:italic>\n                    eceptor\n                    <jats:italic>P<\/jats:italic>\n                    otential\n                    <jats:italic>M<\/jats:italic>\n                    elastatin\n                    <jats:italic>7<\/jats:italic>\n                    (TRPM7) is a divalent-permeant channel-kinase of unknown function expressed in human atrial myocytes and fibroblasts and recently implicated in atrial arrhythmias. We show that TRPM7 is highly expressed in embryonic myocardium and sinoatrial node (SAN).\n                    <jats:italic>Trpm7<\/jats:italic>\n                    disruption in vitro, in cultured embryonic cardiomyocytes, and in vivo in zebrafish and in mice impairs cardiac automaticity. We show that this occurs via reductions in\n                    <jats:italic>Hcn4<\/jats:italic>\n                    mRNA and the pacemaker current,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>f<\/jats:italic>\n                    <\/jats:sub>\n                    , in SAN. We conclude that TRPM7 influences diastolic membrane depolarization and automaticity in SAN via regulation of\n                    <jats:italic>Hcn4<\/jats:italic>\n                    expression.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1311865110","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T23:53:19Z","timestamp":1374537199000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":113,"title":["Ion channel-kinase TRPM\n                    <i>7<\/i>\n                    is required for maintaining cardiac automaticity"],"prefix":"10.1073","volume":"110","author":[{"given":"Rajan","family":"Sah","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute,"},{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Boston, MA 02115;"},{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA 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