{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:37:27Z","timestamp":1791279447117,"version":"4.1.0"},"reference-count":31,"publisher":"National Academy of Sciences","issue":"43","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,10,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Temporal lobe epilepsy (TLE) is a chronic brain disorder characterized by the occurrence of spontaneous recurrent seizures. Much of our knowledge of epilepsy is based on how neurons contribute to this disorder. Here we provide a view in which glial cells (astrocytes) contribute to the progressive development of TLE. We have combined a model of epilepsy that more closely mimics the complex features of seizures in epileptic patients, with astrocyte-specific molecular genetics to identify how astrocytes modulate the progressive development of TLE, including seizure occurrence, brain damage, and behavioral deficits. We provide evidence of the glial regulation of neuronal NMDA receptors in this process. This study identifies astrocytes as a potential therapeutic target for the treatment of epilepsy.<\/jats:p>","DOI":"10.1073\/pnas.1311967110","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T23:17:51Z","timestamp":1381187871000},"page":"17540-17545","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":86,"title":["Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy"],"prefix":"10.1073","volume":"110","author":[{"given":"Jerome","family":"Clasadonte","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin J.","family":"Hines","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"Haydon","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,10,7]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004418"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021909-135843"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2009.10.004"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/med\/9780199746545.003.0046","volume-title":"Jasper\u2019s Basic Mechanisms of the Epilepsies","author":"Clasadonte J","year":"2012","unstructured":"J Clasadonte, PG Haydon, Astrocytes and epilepsy. 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