{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:29:12Z","timestamp":1791473352668,"version":"4.3.4"},"reference-count":30,"publisher":"National Academy of Sciences","issue":"43","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,10,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Epigenetic changes commonly occur in hepatocellular carcinoma (HCC) and are associated with aberrant gene expression. Most studies have focused on epigenetic gene-silencing events; therefore, the mechanism that promotes gene activation in HCC is not well established. We identify an epigenetic activation mechanism whereby menin promotes Yes-associated protein (Yap1) transcription, which is associated with a poor prognosis for HCC patients. Substantial overexpression of the menin\u2013mixed-lineage leukemia complex is associated with increased histone 3 lysine 4 trimethylation at certain loci of the tumor promoter in HCC. Heterozygous ablation of multiple endocrine neoplasia type 1 (\n                    <jats:italic>Men1)<\/jats:italic>\n                    in mice reduces diethylnitrosamine-induced development of HCC. Our findings reveal that menin plays an important epigenetic role in up-regulating Yap1 transcription, leading to liver tumorigenesis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1312022110","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T23:17:51Z","timestamp":1381187871000},"page":"17480-17485","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":77,"title":["Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription"],"prefix":"10.1073","volume":"110","author":[{"given":"Bin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences of Medical College,"},{"name":"State Key Laboratory of Cellular Stress Biology, and"},{"name":"Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Xiamen University, Xiamen 361102, People's Republic of China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences of Medical College,"},{"name":"State Key Laboratory of Cellular Stress Biology, and"},{"name":"Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Xiamen University, Xiamen 361102, People's Republic of China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences of Medical College,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Bin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences of Medical College,"},{"name":"State Key Laboratory of Cellular Stress Biology, and"},{"name":"Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Xiamen University, Xiamen 361102, People's Republic of China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences of Medical College,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yu","family":"Yin","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Xiamen University, Xiamen 361102, People's Republic of China; and"},{"name":"Department of Hepatobiliary Surgery, Affiliated Zhongshan Hospital of Xiamen University, Xiamen 361004, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences of Medical College,"},{"name":"Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Xiamen University, Xiamen 361102, People's Republic of China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jie","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences of Medical College,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Xiamen University, Xiamen 361102, People's Republic of China; and"},{"name":"Department of Hepatobiliary Surgery, Affiliated Zhongshan Hospital of Xiamen University, Xiamen 361004, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Xiamen University, Xiamen 361102, People's Republic of China; 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