{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:14:42Z","timestamp":1790230482171,"version":"4.1.0"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"48","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,11,26]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    About 12% of human genetic disorders involve premature stop codons (PTC) that may produce abnormal, short proteins. Some antibiotics and other compounds have been proposed to restore full-length proteins by reading through PTC. We studied skin cells from xeroderma pigmentosum (XP) patients with different\n                    <jats:italic>PTC<\/jats:italic>\n                    in a DNA repair gene. XP patients have a DNA repair defect and a 10,000-fold increased risk of sunlight-induced skin cancer. Using several readthrough compounds, we found increased levels of DNA repair protein, assembly of DNA repair proteins at the DNA damage site, and repair of UV damage in some XP cells. Even small amounts of increased DNA repair protein may provide potential therapy for XP patients and may reduce disease severity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1312088110","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T23:48:45Z","timestamp":1384213725000},"page":"19483-19488","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":58,"title":["Repair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons"],"prefix":"10.1073","volume":"110","author":[{"given":"Christiane","family":"Kuschal","sequence":"first","affiliation":[{"name":"Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John. 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