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A cellular enzyme termed Itch ubiquitin ligase was identified and found to be essential for influenza viral entry into cells. It allows the viral genome to escape from the trapping of the cells to initiate infection. This host factor fills the critical gap in our understanding of the beginning event of influenza viral infection.<\/jats:p>","DOI":"10.1073\/pnas.1312374110","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T23:17:51Z","timestamp":1381187871000},"page":"17516-17521","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":133,"title":["Pooled RNAi screen identifies ubiquitin ligase Itch as crucial for influenza A virus release from the endosome during virus entry"],"prefix":"10.1073","volume":"110","author":[{"given":"Wen-Chi","family":"Su","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology and"},{"name":"Research Center for Emerging Viruses, China Medical University Hospital, Taichung 40402, Taiwan;"},{"name":"China Medical University, Taichung 40402, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Chia","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hsin","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Medicine and"},{"name":"Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan 70101, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Wei-Che","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Feng","family":"Tung","sequence":"additional","affiliation":[{"name":"National RNAi Core Facility, Academia Sinica, Taipei 11529, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King-Song","family":"Jeng","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and"},{"name":"National RNAi Core Facility, Academia Sinica, Taipei 11529, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M. 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