{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:03:42Z","timestamp":1793833422003,"version":"4.6.1"},"reference-count":30,"publisher":"National Academy of Sciences","issue":"43","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,10,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    22q11 deletion syndrome (22q11DS) is a chromosome disorder that frequently accompanies psychiatric conditions such as schizophrenia. However, it remains elusive how the chromosomal microdeletion causes the mental manifestation. Here we show that a 22q11DS mouse model has deficits in the development of interneurons and hippocampal dentate gyrus and that\n                    <jats:italic>DiGeorge syndrome critical region gene 8 (Dgcr8)<\/jats:italic>\n                    , a microprocessor of microRNA and one of the genes in 22q11, underlies these neurodevelopmental abnormalities. Dgcr8 regulates Chemokine receptor 4\/Chemokine ligand 12 (Cxcr4\/Cxcl12; Sdf1) signaling, which is indispensable for interneuron and dentate gyrus development. Finally, we observe decreased expression of CXCL12 in olfactory neurons from sporadic schizophrenia. Given the increased risk of 22q11DS in schizophrenia, the overall study suggests that CXCR4\/CXCL12 signaling may represent a common downstream mediator in the pathophysiology of schizophrenia.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1312661110","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T23:17:51Z","timestamp":1381187871000},"page":"17552-17557","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":80,"title":["Deficits in microRNA-mediated Cxcr4\/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model"],"prefix":"10.1073","volume":"110","author":[{"given":"Michihiro","family":"Toritsuka","sequence":"first","affiliation":[{"name":"Research Institute, Shiga Medical Center, Shiga 524-8524, Japan;"},{"name":"Department of Psychiatry, Faculty of Medicine, Nara Medical University, Nara 634-8522, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohei","family":"Kimoto","sequence":"additional","affiliation":[{"name":"Research Institute, Shiga Medical Center, Shiga 524-8524, Japan;"},{"name":"Department of Psychiatry, Faculty of Medicine, Nara Medical University, Nara 634-8522, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazue","family":"Muraki","sequence":"additional","affiliation":[{"name":"Research Institute, Shiga Medical Center, Shiga 524-8524, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Landek-Salgado","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasue","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hiyama","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287;"},{"name":"Pharmacology Research Laboratories, Astellas Pharma, Inc., Ibaragi 305-8585, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Tajinda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287;"},{"name":"Pharmacology Research Laboratories, Astellas Pharma, Inc., Ibaragi 305-8585, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Keni","sequence":"additional","affiliation":[{"name":"Pharmacology Research Laboratories, Astellas Pharma, Inc., Ibaragi 305-8585, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Illingworth","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology, University of Salerno, Fisciano, 84084 Salerno, Italy; 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