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Further, SAM riboswitches regulate expression of genes essential for survival and\/or virulence in medically important pathogens, suggesting they might be important targets for the development of new antimicrobial agents. Our studies reveal the atomic-resolution structure of a unique peripheral architecture that supports a SAM-binding core shared among three families that make up the \u201cSAM clan\u201d and how this subdomain facilitates both ligand binding and gene regulation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1312918111","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T22:50:54Z","timestamp":1398120654000},"page":"6624-6629","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":63,"title":["Structural basis for diversity in the SAM clan of riboswitches"],"prefix":"10.1073","volume":"111","author":[{"given":"Jeremiah J.","family":"Trausch","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis E.","family":"Reyes","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip E.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Knight","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry and"},{"name":"Howard Hughes Medical Institute, University of Colorado, Boulder, CO, 80309-0596"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Batey","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,4,21]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003566","article-title":"Riboswitches and the RNA world","volume":"4","author":"Breaker RR","year":"2012","unstructured":"RR Breaker, Riboswitches and the RNA world. 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