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We demonstrate that mice selectively lacking the capacity to up-regulate the generation of prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    with inflammation develop an AERD-like phenotype that depends critically on platelets and thromboxane receptors, which drive transcellular synthesis of cysLTs, which, in turn, activate mast cells with aspirin challenge. The findings suggest a role for antiplatelet or thromboxane-selective antagonists as treatments for AERD.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1313185110","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T00:24:52Z","timestamp":1380673492000},"page":"16987-16992","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":108,"title":["Prostaglandin E\n                    <sub>2<\/sub>\n                    deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes"],"prefix":"10.1073","volume":"110","author":[{"given":"Tao","family":"Liu","sequence":"first","affiliation":[{"name":"Departments of aMedicine and"},{"name":"Jeff and Penny Vinik Center for Allergic Disease Research, Division of Rheumatology, Immunology, and Allergy, Brigham and Women\u2019s Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya M.","family":"Laidlaw","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"},{"name":"Pediatrics, Harvard Medical School, Boston, MA 02115; and"},{"name":"Jeff and Penny Vinik Center for Allergic Disease Research, Division of Rheumatology, Immunology, and Allergy, Brigham and Women\u2019s Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard R.","family":"Katz","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"},{"name":"Jeff and Penny Vinik Center for Allergic Disease Research, Division of Rheumatology, Immunology, and Allergy, Brigham and Women\u2019s Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Boyce","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"},{"name":"Pediatrics, Harvard Medical School, Boston, MA 02115; and"},{"name":"Jeff and Penny Vinik Center for Allergic Disease Research, Division of Rheumatology, Immunology, and Allergy, Brigham and Women\u2019s Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,10]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.7.569"},{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","unstructured":"Kasper L S\u0142adek K Bochenek G Duplaga M Szczeklik A (2009) [The frequency of hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) in the population of adult asthmatics in Poland based on an epidemiological questionnaire]. 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