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Here, we demonstrate that wingless-type (WNT) acts as a paracrine signal from estrogen\/progesterone receptor-rich mature cells to activate the canonical \u03b2-catenin pathway in leiomyoma stem cells. Our findings suggest a paracrine role for the canonical WNT pathway in the growth of leiomyoma tumor.<\/jats:p>","DOI":"10.1073\/pnas.1313650110","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T02:09:28Z","timestamp":1380593368000},"page":"17053-17058","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":169,"title":["Paracrine activation of WNT\/\u03b2-catenin pathway in uterine leiomyoma stem cells promotes tumor growth"],"prefix":"10.1073","volume":"110","author":[{"given":"Masanori","family":"Ono","sequence":"first","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"},{"name":"Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yin","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Navarro","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly B.","family":"Moravek","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"V","given":"John S.","family":"Coon","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy A.","family":"Druschitz","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanida Ann","family":"Serna","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenan","family":"Qiang","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh S.","family":"Malpani","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Ma","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihangir Mutlu","family":"Ercan","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navdha","family":"Mittal","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Monsivais","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Dyson","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Yemelyanov","sequence":"additional","affiliation":[{"name":"Medicine, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Chakravarti","sequence":"additional","affiliation":[{"name":"Departments of aObstetrics and Gynecology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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