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This inhibitory mechanism is likely responsible for disrupting the structure of the synapse, compromising synaptic transmission and causing disease. Our findings therefore suggest that therapeutic strategies designed to increase MuSK activity may prove effective in treating MuSK MG. Moreover, our studies provide mechanistic understanding of an IgG4-mediated autoimmune disease and may shed light on the mechanisms of other IgG4-mediated autoimmune diseases.<\/jats:p>","DOI":"10.1073\/pnas.1313944110","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T23:57:30Z","timestamp":1386028650000},"page":"20783-20788","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":288,"title":["MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4"],"prefix":"10.1073","volume":"110","author":[{"given":"Maartje G.","family":"Huijbers","sequence":"first","affiliation":[{"name":"Department of Neurology,"},{"name":"Department of Human Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology Program, Helen L. and Martin S. 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