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We demonstrate that double TLR8\/9-deficient mice have increased abnormalities characteristic of SLE and that both TLR8 and TLR9 keep under control TLR7-mediated lupus, but they act on different cell types. TLR8 controls TLR7 function on dendritic cells, and TLR9 restrains TLR7 response on B cells. These TLR interactions have to be taken into account when novel therapeutic approaches are developed that target the blocking of TLRs.<\/jats:p>","DOI":"10.1073\/pnas.1314121111","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T21:39:11Z","timestamp":1389649151000},"page":"1497-1502","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":134,"title":["TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL\/6 mice"],"prefix":"10.1073","volume":"111","author":[{"given":"Benoit","family":"Desnues","sequence":"first","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University UM 2, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche 1104, 13288 Marseille, France; and"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 7280, 13288 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Beatriz","family":"Macedo","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University UM 2, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche 1104, 13288 Marseille, France; 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