{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:25:16Z","timestamp":1781105116889,"version":"3.54.1"},"reference-count":38,"publisher":"National Academy of Sciences","issue":"46","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,11,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>In the last decade there has been an exponential increase in knowledge about the genetic basis of complex human traits. It is not clear, however, to what extent this knowledge can be used as a starting point for drug identification, one of the central hopes of the human genome project. Here, we report that by using genomic information related to aversive memory\u2014a trait central to posttraumatic stress disorder\u2014we identified several potential drug targets and compounds. In a subsequent pharmacological study with one of the identified compounds, we found a drug-induced reduction of aversive memory. These findings indicate that genomic information can be used as a starting point for the identification of memory-modulating compounds.<\/jats:p>","DOI":"10.1073\/pnas.1314478110","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T22:57:55Z","timestamp":1382396275000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":23,"title":["Human genome\u2013guided identification of memory-modulating drugs"],"prefix":"10.1073","volume":"110","author":[{"given":"Andreas","family":"Papassotiropoulos","sequence":"first","affiliation":[{"name":"Department of Psychology, Division of Molecular Neuroscience,"},{"name":"Psychiatric University Clinics,"},{"name":"Transfaculty Research Platform,"},{"name":"Department Biozentrum, Life Sciences Training Facility, 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