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Collectively, the functional and crystallographic results reported in this work uncover intricate interactions of these elements within the Na\n                    <jats:sub>v<\/jats:sub>\n                    -channel signaling complex and establish a key role for \u03b2-subunits in shaping Na\n                    <jats:sub>v<\/jats:sub>\n                    1.2 pharmacology. An important concept emerging from our results is that \u03b2-subunits provide exciting opportunities for designing new therapeutic strategies to correct their abnormal behaviors.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1314557110","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T23:57:30Z","timestamp":1386028650000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":75,"title":["Crystallographic insights into sodium-channel modulation by the \u03b24 subunit"],"prefix":"10.1073","volume":"110","author":[{"given":"John","family":"Gilchrist","sequence":"first","affiliation":[{"name":"Department of Physiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and"},{"name":"the cLife Sciences Institute, University of British Columbia, Vancouver, V6T 1Z3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Van Petegem","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and"},{"name":"the cLife Sciences Institute, University of British Columbia, Vancouver, V6T 1Z3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bosmans","sequence":"additional","affiliation":[{"name":"Department of Physiology and"},{"name":"Solomon H. 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