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ATF3 overexpression in motor neurons in an ALS mouse model modifies gene expression and drives the neurons into a prosurvival and proregenerative state, increasing motor neuron survival and maintaining axonal connection with muscle by promoting axonal sprouting. ATF3 overexpression results in markedly improved muscle strength and function and delayed disease onset but only slightly increased lifespan. Molecular mechanisms that promote axonal sprouting could substantially improve quality of life in ALS, although additional approaches will be required to overcome progressive motor neuron deterioration.<\/jats:p>","DOI":"10.1073\/pnas.1314826111","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T21:39:11Z","timestamp":1389649151000},"page":"1622-1627","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":64,"title":["ATF3 expression improves motor function in the ALS mouse model by promoting motor neuron survival and retaining muscle innervation"],"prefix":"10.1073","volume":"111","author":[{"given":"Rhona","family":"Seijffers","sequence":"first","affiliation":[{"name":"F. M. 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