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Here we show that although muscle-restricted coiled-coil protein (MURC)\/Cavin-4, a muscle-specific caveola component, is dispensable for caveolar formation in cardiomyocytes, MURC\/Cavin-4 serves as an ERK-recruiting protein in the caveolae within cardiomyocytes. The recruiting function of MURC\/Cavin-4 is necessary to elicit efficient signaling of the \u03b11-adrenergic receptor\u2013ERK cascade in concentric cardiac hypertrophy. Our findings provide unique insight into the molecular mechanisms underlying caveola-mediated signaling in cardiac hypertrophy.<\/jats:p>","DOI":"10.1073\/pnas.1315359111","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T21:44:15Z","timestamp":1393278255000},"page":"3811-3816","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":67,"title":["MURC\/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by \u03b11-adrenergic receptors"],"prefix":"10.1073","volume":"111","author":[{"given":"Takehiro","family":"Ogata","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular 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