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The transgenic mice developed B-cell lymphomas, and the transcriptome analysis suggested the involvement of PI3K signaling in B lymphocytes, B-cell receptor signaling, GADD45 signaling, and IL-4 signaling pathways in these disorders. Our results provide direct experimental evidence confirming that the miR-17\u223c92 cluster, which is amplified in human B-cell lymphoma, also is oncogenic when overexpressed in mice.<\/jats:p>","DOI":"10.1073\/pnas.1315365110","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T22:57:55Z","timestamp":1382396275000},"page":"18208-18213","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":69,"title":["B-cell malignancies in microRNA E\u03bc-miR-17\u223c92 transgenic mice"],"prefix":"10.1073","volume":"110","author":[{"given":"Sukhinder K.","family":"Sandhu","sequence":"first","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Fassan","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210;"},{"name":"ARC-NET Research Centre, University of Verona, VR 37134, Verona, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Volinia","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210;"},{"name":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, FE 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lovat","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Balatti","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Pekarsky","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo M.","family":"Croce","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,10,21]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1158\/0008-5472.CAN-03-3773","article-title":"Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma","volume":"64","author":"Ota A","year":"2004","unstructured":"A Ota, et al., Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. 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