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Specifically, we find that water-sensing taste signals alter nutrient homeostasis and regulate a glucagon-like signaling pathway to govern production of internal water production. This metabolic alteration likely serves as a response to water sensory information. This control of metabolic state, in turn, determines the organism\u2019s long-term health and lifespan. Our studies, then, provide a framework for understanding sensory control of aging as well as several targets to potentially maximize organismal health.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1315461111","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T04:53:58Z","timestamp":1399956838000},"page":"8137-8142","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":88,"title":["Water sensor\n                    <i>ppk28<\/i>\n                    modulates\n                    <i>Drosophila<\/i>\n                    lifespan and physiology through AKH signaling"],"prefix":"10.1073","volume":"111","author":[{"given":"Michael J.","family":"Waterson","sequence":"first","affiliation":[{"name":"Program in Cellular and Molecular Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Y.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M.","family":"Harvanek","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology,"},{"name":"Medical Scientist Training Program, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Ostojic","sequence":"additional","affiliation":[{"name":"Growth Control Unit, Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Alcedo","sequence":"additional","affiliation":[{"name":"Growth Control Unit, Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland; and"},{"name":"Department of Biological Sciences, Wayne State University, Detroit, MI 48202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Pletcher","sequence":"additional","affiliation":[{"name":"Program in Cellular and Molecular Biology,"},{"name":"Department of Molecular and Integrative Physiology,"},{"name":"Geriatrics Center, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00816-X"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.002"},{"key":"e_1_3_3_3_2","first-page":"325","article-title":"The genetic mechanisms of the influence of the light regime on the lifespan of Drosophila melanogaster","volume":"3","author":"Shostal OA","year":"2012","unstructured":"OA Shostal, AA Moskalev, The genetic mechanisms of the influence of the light regime on the lifespan of Drosophila melanogaster. 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