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Herein we identify a natural mouse IgG antibody that recognizes fibrinogen deposited in human AAA tissues and induces aneurysm in a mouse model through activation of the complement lectin pathway (LP). Conversely, absence of antibody or complement proteins abrogates AAA development. These results support the concept that antibody directed against aortic wall epitopes initiates LP activation that culminates in AAA formation. The antibody response and complement LP may provide therapeutic targets for halting disease progression.<\/jats:p>","DOI":"10.1073\/pnas.1315512110","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T23:37:12Z","timestamp":1383003432000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":42,"title":["Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation"],"prefix":"10.1073","volume":"110","author":[{"given":"Hui-fang","family":"Zhou","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Bertram","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke E.","family":"Springer","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, Washington University in St. Louis, St. Louis, MO 63124"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Curci","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, Washington University in St. Louis, St. Louis, MO 63124"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E.","family":"Hourcade","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine T. 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