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Here, we show cell-autonomous activation of a mitochondrial cell death pathway during initial stages of muscle cell hypertrophy, a signal that is essential and sufficient to promote hypertrophy. Targeting individual cell death proteins may offer an effective means to limit the initial stage of cardiac disease, and forgo the transition to heart failure.<\/jats:p>","DOI":"10.1073\/pnas.1315587110","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T23:17:51Z","timestamp":1381187871000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":59,"title":["Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy"],"prefix":"10.1073","volume":"110","author":[{"given":"Charis","family":"Putinski","sequence":"first","affiliation":[{"name":"Ottawa Hospital Research Institute, Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital, Ottawa, ON, Canada K1H 8L6;"},{"name":"Department of Cellular and Molecular Medicine, Faculty of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Abdul-Ghani","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute, Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital, Ottawa, ON, Canada K1H 8L6;"},{"name":"Department of Cellular and Molecular Medicine, Faculty of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Stiles","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute, Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital, Ottawa, ON, Canada K1H 8L6;"},{"name":"Department of Cellular and Molecular Medicine, Faculty of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Brunette","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute, Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital, Ottawa, ON, Canada K1H 8L6;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Dick","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute, Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital, Ottawa, ON, Canada K1H 8L6;"},{"name":"Department of Cellular and Molecular Medicine, Faculty of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasan","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Faculty of Medicine, and"},{"name":"Division of Cardiology, Canadian Molecular Imaging Centre of Excellence, University of Ottawa Heart Institute, Ottawa, ON, Canada K1Y 4W7; and"},{"name":"Nordion, Ottawa, ON, Canada K2K 1X8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn A.","family":"Megeney","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute, Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital, Ottawa, ON, Canada K1H 8L6;"},{"name":"Department of Cellular and Molecular Medicine, Faculty of Medicine, and"},{"name":"Department of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,10,7]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)80027-5"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.260729"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/0470029331.ch2","article-title":"Control of cardiac hypertrophy and heart failure by histone acetylation\/deacetylation","volume":"274","author":"Olson EN","year":"2006","unstructured":"EN Olson, J Backs, TA McKinsey, Control of cardiac hypertrophy and heart failure by histone acetylation\/deacetylation. 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