{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:49:16Z","timestamp":1792550956993,"version":"4.5.0"},"reference-count":40,"publisher":"National Academy of Sciences","issue":"40","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Mitochondria are dynamic organelles that constantly fuse and fragment while acting as central hubs of energy production, apoptosis regulation, and Ca\n                    <jats:sup>++<\/jats:sup>\n                    signaling, therefore emerging as potential targets of pathogens. We previously showed that the foodborne bacterial pathogen\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    interferes with the dynamics and function of the host cell mitochondrial network via the bacterial toxin listeriolysin O (LLO). In this study, we analyze the effects of LLO on key players known to be involved in mitochondrial dynamics and show that the fission protein dynamin-like protein 1 (Drp1) is not essential for LLO-induced fragmentation of the mitochondrial network, whereas the endoplasmic reticulum (ER) plays an important role, suggesting a unique Drp1-independent and ER-dependent mechanism that is different from the canonical fission machinery.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1315784110","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T00:23:51Z","timestamp":1379377431000},"page":"16003-16008","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":128,"title":["Atypical mitochondrial fission upon bacterial infection"],"prefix":"10.1073","volume":"110","author":[{"given":"Fabrizia","family":"Stavru","sequence":"first","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Institut Pasteur, 75015 Paris, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 604, 75015 Paris, France;"},{"name":"Institut National de la Recherche Agronomique Unit\u00e9 Sous Contrat 2020, 75015 Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Institut Pasteur, 75015 Paris, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 604, 75015 Paris, France;"},{"name":"Institut National de la Recherche Agronomique Unit\u00e9 Sous Contrat 2020, 75015 Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Youle","sequence":"additional","affiliation":[{"name":"Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Cossart","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Institut Pasteur, 75015 Paris, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 604, 75015 Paris, France;"},{"name":"Institut National de la Recherche Agronomique Unit\u00e9 Sous Contrat 2020, 75015 Paris, France; 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