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We report that (\n                    <jats:italic>i<\/jats:italic>\n                    ) anthrax lethal toxin enters macrophages by associating with higher-order actin filaments that provide the dynamic force for membrane invagination during endocytic trafficking of integrin-containing focal adhesion complexes (FACs) and (\n                    <jats:italic>ii<\/jats:italic>\n                    ) calpain-mediated cleavage of talin-1, which anchors FACs at the cell surface, facilitates such exploitation. 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