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Conversely, we showed that CD8-independent T cells are signaled in a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -independent, PI3K-dependent manner. By assessing the physical and functional affinities, signaling, and TCR repertoires of CD8-dependent and -independent T cells, we uncovered correlates between effector functions, their triggering, and the TCR repertoires. We suggest that the docking orientations of TCR\u2013MHC complexes may influence CD8\n                    <jats:sup>+<\/jats:sup>\n                    T-cell signaling and hence their functions. Together, these data argue that signaling events rather than affinity determine CD8 dependency and that the duality of the CD8 compartment may provide the organisms with broader protective immunity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1317847111","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T20:22:49Z","timestamp":1393964569000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":5,"title":["Duality of the murine CD8 compartment"],"prefix":"10.1073","volume":"111","author":[{"given":"Rapha\u00ebl","family":"Genolet","sequence":"first","affiliation":[{"name":"Ludwig Centre for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Leignadier","sequence":"additional","affiliation":[{"name":"Ludwig Centre for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magne","family":"\u00d8ster\u00e5s","sequence":"additional","affiliation":[{"name":"Fasteris SA, 1228 Plan-les-Ouates, Switzerland; 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