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Previously, we showed in a mouse model that disease initiation for prostate cancer with a basal cell origin requires and is limited by basal-to-luminal differentiation and that prostatic inflammation induced by bacterial infection accelerates disease initiation by enhancing basal-to-luminal differentiation. Collectively, our results show that inflammation-induced microenvironmental changes alter the prostate epithelial lineage differentiation program, and we propose this alteration as a distinct and complementary process through which inflammation promotes tumor initiation.<\/jats:p>","DOI":"10.1073\/pnas.1318157111","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T23:28:01Z","timestamp":1387841281000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":159,"title":["Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin"],"prefix":"10.1073","volume":"111","author":[{"given":"Oh-Joon","family":"Kwon","sequence":"first","affiliation":[{"name":"Departments of aMolecular and Cellular Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of aMolecular and Cellular Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Ittmann","sequence":"additional","affiliation":[{"name":"Pathology and Immunology and the"},{"name":"Michael E. 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