{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:13:46Z","timestamp":1792318426754,"version":"4.4.0"},"reference-count":25,"publisher":"National Academy of Sciences","issue":"4","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,1,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Infection of pathogenic microbes induces the body to produce cytokines, which are mediators of inflammation. TNF\u03b1 and IL-1\u03b2 are two important proinflammatory cytokines that trigger a series of cellular reactions, leading to induction of downstream genes and inflammation. Understanding how the cellular reactions are triggered by the proinflammatory cytokines is important for deciphering the molecular mechanisms of inflammation. In this study, we identified a protein called TRIM38, which negatively regulates TNF\u03b1- and IL-1\u03b2\u2013triggered cellular reactions by causing degradation of TAB2\/3, two cellular components essential for TNF\u03b1- and IL-1\u03b2\u2013triggered cellular response. This study reveals a mechanism by which cells keep the inflammatory response in check to avoid excessive harmful immune response and may provide clues on treatments of inflammation.<\/jats:p>","DOI":"10.1073\/pnas.1318227111","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T21:39:11Z","timestamp":1389649151000},"page":"1509-1514","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":139,"title":["TRIM38 inhibits TNF\u03b1- and IL-1\u03b2\u2013triggered NF-\u03baB activation by mediating lysosome-dependent degradation of TAB2\/3"],"prefix":"10.1073","volume":"111","author":[{"given":"Ming-Ming","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe-Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bing","family":"Shu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.13"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183434.111"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3138pe29"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2065"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8064-8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0805-758"},{"key":"e_1_3_3_7_2","first-page":"cm1","article-title":"Interleukin-1 (IL-1) pathway","volume":"3","author":"Weber A","year":"2010","unstructured":"A Weber, P Wasiliew, M Kracht, Interleukin-1 (IL-1) pathway. 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