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Thus, exemestane is potently anti-inflammatory and antioxidant and can thereby protect against development of cancer and chronic degenerative diseases. Moreover, these activities are synergistic with sulforaphane and other cytoprotective phytochemicals. Use of such combinations could therefore provide a valuable strategy for reducing the risk of a variety of other malignancies and age-related chronic diseases.<\/jats:p>","DOI":"10.1073\/pnas.1318247110","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T20:58:48Z","timestamp":1383598728000},"page":"19065-19070","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":70,"title":["Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention"],"prefix":"10.1073","volume":"110","author":[{"given":"Hua","family":"Liu","sequence":"first","affiliation":[{"name":"The Lewis B. and Dorothy Cullman Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Talalay","sequence":"additional","affiliation":[{"name":"The Lewis B. and Dorothy Cullman Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,11,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-11-0572"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/128_2012_339"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2013.02.015"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1610"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006-0281"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200969070-00007"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103507"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1106052"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.3122"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0915"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn693"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(88)90129-X"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.21.8261"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520120102"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051632198"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.163485"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307301101"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-011-0674-5"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.6.2399"},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-59259-768-0_1","volume-title":"Cancer Chemoprevention 2: Strategies for Cancer Chemoprevention","author":"Pezzuto JM","year":"2005","unstructured":"JM Pezzuto, et al., Characterization of natural product chemopreventive agents. 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