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Our studies show that bone inflammation in this model is mediated by the cytokine IL-1\u03b2, but that the disease is independent of the nucleotide-binding domain, leucine-rich repeat-containing family, pyrin domain-containing 3 (NLRP3) inflammasome and caspase-1, which is different from most other IL-1\u2013mediated disorders. Further, we implicate neutrophils and neutrophil serine proteases in disease pathogenesis. 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