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The repertoire of bone marrow memory T cells is enriched for systemic pathogens representing persistent, recent, and childhood challenges. In terms of absolute numbers, memory T cells specific for systemic antigens are maintained predominantly in the bone marrow, in particular those representing historic encounters.<\/jats:p>","DOI":"10.1073\/pnas.1318731111","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T21:49:00Z","timestamp":1402436940000},"page":"9229-9234","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":187,"title":["Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory"],"prefix":"10.1073","volume":"111","author":[{"given":"Anna","family":"Okhrimenko","sequence":"first","affiliation":[{"name":"Cell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim R.","family":"Gr\u00fcn","sequence":"additional","affiliation":[{"name":"Bioinformatics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Westendorf","sequence":"additional","affiliation":[{"name":"Cell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Fang","sequence":"additional","affiliation":[{"name":"Cell Biology,"},{"name":"Signal Transduction, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Reinke","sequence":"additional","affiliation":[{"name":"Core Unit Cell Harvesting, Berlin-Brandenburg Center for Regenerative Therapies and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"von Roth","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgi","family":"Wassilew","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja A.","family":"K\u00fchl","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology, Charit\u00e9 University of Medicine Berlin, 12200 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kudernatsch","sequence":"additional","affiliation":[{"name":"Clinical Tumor Immunology and Immunemonitoring, Institute for Medical Immunology, Charit\u00e9 University of Medicine Berlin, 13353 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya","family":"Demski","sequence":"additional","affiliation":[{"name":"Clinical Tumor Immunology and Immunemonitoring, Institute for Medical Immunology, Charit\u00e9 University of Medicine Berlin, 13353 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Scheibenbogen","sequence":"additional","affiliation":[{"name":"Clinical Tumor Immunology and Immunemonitoring, Institute for Medical Immunology, Charit\u00e9 University of Medicine Berlin, 13353 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Tokoyoda","sequence":"additional","affiliation":[{"name":"Osteoimmunology, Deutsches Rheuma-Forschungszentrum Berlin, 10117 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mairi A.","family":"McGrath","sequence":"additional","affiliation":[{"name":"Cell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Raftery","sequence":"additional","affiliation":[{"name":"Institute of Virology, Charit\u00e9 University of Medicine Berlin, 10117 Berlin, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Sch\u00f6nrich","sequence":"additional","affiliation":[{"name":"Institute of Virology, Charit\u00e9 University of Medicine Berlin, 10117 Berlin, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Serra","sequence":"additional","affiliation":[{"name":"Cell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Dong","family":"Chang","sequence":"additional","affiliation":[{"name":"Cell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Radbruch","sequence":"additional","affiliation":[{"name":"Cell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Dong","sequence":"additional","affiliation":[{"name":"Cell Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.immuni.2009.03.015","article-title":"Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow","volume":"30","author":"Tokoyoda K","year":"2009","unstructured":"K Tokoyoda, et al., Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow. 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