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Remarkably, two distinct sets of foci are found, one containing RNAs transcribed in the sense direction and the other containing antisense RNAs. Antisense oligonucleotides (ASOs) are developed that selectively target sense strand repeat-containing RNAs and reduce sense-oriented foci without affecting overall\n                    <jats:italic>C9orf72<\/jats:italic>\n                    expression. Importantly, reducing\n                    <jats:italic>C9orf72<\/jats:italic>\n                    expression does not cause behavioral or pathological changes in mice and induces only a few genome-wide mRNA alterations. These findings establish ASO-mediated degradation of repeat-containing RNAs as a significant therapeutic approach.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1318835110","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T23:12:08Z","timestamp":1383088328000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":530,"title":["Targeted degradation of sense and antisense\n                    <i>C9orf72<\/i>\n                    RNA foci as therapy for ALS and frontotemporal degeneration"],"prefix":"10.1073","volume":"110","author":[{"given":"Clotilde","family":"Lagier-Tourenne","sequence":"first","affiliation":[{"name":"Departments of aNeurosciences,"},{"name":"Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 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