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RRV infection of osteoblasts resulted in increased receptor activator of nuclear factor-kappaB ligand (RANKL) but decreased osteoprotegerin (OPG). We are the first to report that alphavirus infection results in bone loss in an established RRV murine model and that this bone loss is prevented by IL-6 inhibition. These findings reveal that RRV can disrupt bone homeostasis and that osteoblasts play an important role in alphavirus-induced arthritis by regulating IL-6 and contribute to bone loss by disrupting the RANKL\/OPG balance.<\/jats:p>","DOI":"10.1073\/pnas.1318859111","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T23:58:43Z","timestamp":1397519923000},"page":"6040-6045","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":123,"title":["Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss"],"prefix":"10.1073","volume":"111","author":[{"given":"Weiqiang","family":"Chen","sequence":"first","affiliation":[{"name":"Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suan-Sin","family":"Foo","sequence":"additional","affiliation":[{"name":"Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor E.","family":"Rulli","sequence":"additional","affiliation":[{"name":"Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Taylor","sequence":"additional","affiliation":[{"name":"Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Ching","family":"Sheng","sequence":"additional","affiliation":[{"name":"Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara J.","family":"Herrero","sequence":"additional","affiliation":[{"name":"Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda L.","family":"Herring","sequence":"additional","affiliation":[{"name":"Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett A.","family":"Lidbury","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel W.","family":"Li","sequence":"additional","affiliation":[{"name":"Trauma and Orthopaedic Research Laboratory, Department of Surgery, The Medical School, The Australian National University, John Curtin School of Medical Research, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.","family":"Walsh","sequence":"additional","affiliation":[{"name":"St. Vincent\u2019s Institute, Fitzroy VIC 3065, Australia;"},{"name":"Department of Medicine at St. Vincent\u2019s Hospital, The University of Melbourne, Fitzroy VIC 3065, Australia; 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