{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:11:49Z","timestamp":1783537909112,"version":"3.55.0"},"reference-count":60,"publisher":"National Academy of Sciences","issue":"47","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,11,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>We examined the variability of neuron packing densities across cortical regions and areas in two baboons with spontaneous, untreated epilepsy and two baboons without epilepsy. The two baboons without epilepsy had the distribution of neocortical neurons expected for Old World monkeys and baboons, whereas the baboons with untreated epilepsy had reduced numbers of cortical neurons overall, with the greatest reductions in motor and frontal areas of the cortex, and with little or no reduction in the primary visual cortex. The results suggest that neuron loss may follow untreated seizure activity, and this loss is greatest in areas of the cortex related to motor functions.<\/jats:p>","DOI":"10.1073\/pnas.1318894110","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T20:58:48Z","timestamp":1383598728000},"page":"19107-19112","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":29,"title":["Epileptic baboons have lower numbers of neurons in specific areas of cortex"],"prefix":"10.1073","volume":"110","author":[{"given":"Nicole A.","family":"Young","sequence":"first","affiliation":[{"name":"Department of Psychology, Vanderbilt University, Nashville, TN 37240;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. \u00c1kos","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Health Science Center, San Antonio, TX 78229;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clyde F.","family":"Phelix","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Flaherty","sequence":"additional","affiliation":[{"name":"Flow Cytometry Shared Resource, Vanderbilt University Medical Center, Nashville TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Balaram","sequence":"additional","affiliation":[{"name":"Department of Psychology, Vanderbilt University, Nashville, TN 37240;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kallie B.","family":"Foust-Yeoman","sequence":"additional","affiliation":[{"name":"Department of Psychology, Vanderbilt University, Nashville, TN 37240;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Psychology, Vanderbilt University, Nashville, TN 37240;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon H.","family":"Kaas","sequence":"additional","affiliation":[{"name":"Department of Psychology, Vanderbilt University, Nashville, TN 37240;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,11,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20215"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06153.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000230171.23913.cf"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03413.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182563b44"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12129"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00577.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02770.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr290"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr291"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(91)90085-L"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-02-01463.1995"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12569-6"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902790206"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010356107"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2013.00030"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.6.648"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)35008-8"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.12.055"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.12.012"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.07.002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(98)00055-2"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.5.1377"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)35010-6"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)35026-X"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02730-X"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2006.11.008"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.12.021"},{"key":"e_1_3_3_29_2","first-page":"147","volume-title":"Advances in Neurology","author":"Meldrum BS","year":"1975","unstructured":"BS Meldrum, JJ Pappy, MF Toure, JB Brierley, Four models for studying cerebral lesions secondary to epileptic seizures. Advances in Neurology, eds BS Meldrum, CD Marsden (Raven Press, New York) Vol 10, 147\u2013161 (1975)."},{"key":"e_1_3_3_30_2","first-page":"2429","article-title":"Photomyoclonic seizures in the baboon, Papio papio","volume":"38","author":"Killam EK","year":"1979","unstructured":"EK Killam, Photomyoclonic seizures in the baboon, Papio papio. Fed Proc 38, 2429\u20132433 (1979).","journal-title":"Fed Proc"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.20018"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2005.05.003"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2010.10.016"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874440001105010206"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2012.02.016"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2013.02.012"},{"key":"e_1_3_3_37_2","first-page":"5","article-title":"A rapid and reliable method of counting neurons and other cells in brain tissue: A comparison of flow cytometry and manual counting methods","volume":"4","author":"Collins CE","year":"2010","unstructured":"CE Collins, NA Young, DK Flaherty, DC Airey, JH Kaas, A rapid and reliable method of counting neurons and other cells in brain tissue: A comparison of flow cytometry and manual counting methods. Front Neuroanat 4, 5 (2010).","journal-title":"Front Neuroanat"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2012.00027"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1159\/000324862"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(95)00121-2"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(01)00130-0"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.05.013"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04789.2001"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903300207"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00704-X"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960805)371:4<649::AID-CNE12>3.0.CO;2-E"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.10.1071"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1999.0789"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-17-j0002.2001"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00652-9"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00164.2011"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.1.98"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.12.028"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/8.8.730"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199909290-00019"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.238154"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.12.008"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(02)00811-0"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2009.04.002"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00318.x"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1318894110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:34:06Z","timestamp":1649806446000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1318894110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,4]]},"references-count":60,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2013,11,19]]}},"alternative-id":["10.1073\/pnas.1318894110"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1318894110","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,4]]},"assertion":[{"value":"2013-11-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}