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Here, we show that loss of\n                    <jats:italic>Drosophila<\/jats:italic>\n                    TGF-\u03b2\/Activin-like ligand Dawdle (Daw) causes major alterations in larval metabolic activity, including accumulation of tricarboxylic acid cycle intermediates, acidification of hemolymph pH, and misregulation of insulin signaling and nuclear-encoded mitochondrial gene expression. These metabolic defects lead to a food-dependent lethality phenotype, suggesting that Daw likely influences environmental adaptability via its modulation of several central metabolic processes. These observations, coupled with previous findings in mammals and\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    , highlight a potentially conserved role for TGF-\u03b2\/Activin signaling in regulating important metabolic processes across the animal kingdom and may have clinical implications.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1319116111","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T02:13:03Z","timestamp":1396318383000},"page":"5729-5734","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":103,"title":["Systemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in\n                    <i>Drosophila melanogaster<\/i>"],"prefix":"10.1073","volume":"111","author":[{"given":"Arpan C.","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Genetics, Cell Biology, and 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