{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:49:08Z","timestamp":1793173748094,"version":"4.5.0"},"reference-count":56,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,3,11]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Residual micrometastases following standard therapies limit our ability to cure many cancers. This article demonstrates a new therapy and visualization platform that targets residual cancer micrometastases with enhanced sensitivity and selectivity based on \u201ctumor-targeted activation.\u201d This targeted activation feature not only provides a potent therapeutic arm that is effective against chemoresistant disease while minimizing side effects due to nonspecific toxicities but also enables micrometastasis imaging in common sites of disease recurrence to screen patients harboring residual tumor deposits. This approach offers promise for treating and monitoring drug-resistant micrometastases presently \u201cinvisible\u201d to clinicians.<\/jats:p>","DOI":"10.1073\/pnas.1319493111","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T23:28:41Z","timestamp":1393457321000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":114,"title":["Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates"],"prefix":"10.1073","volume":"111","author":[{"given":"Bryan Q.","family":"Spring","sequence":"first","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan O.","family":"Abu-Yousif","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akilan","family":"Palanisami","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Mai","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Anbil","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Bryan","family":"Sears","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence B.","family":"Mensah","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Sibel","family":"Erdem","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Oliva","sequence":"additional","affiliation":[{"name":"Departments of bPathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayyaba","family":"Hasan","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;"},{"name":"Dermatology, Massachusetts General Hospital, Boston, MA 02114; and"},{"name":"Division of Health Sciences and Technology, Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,2,26]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1611"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2644"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.44"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100105"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2622"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.012"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0901557"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120733109"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-999-0013-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00826.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2397-2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji314"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mla.2006.05.006"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1894"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2472"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70665-9"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910261107"},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.4049\/jimmunol.130.3.1473","article-title":"Photoimmunotherapy: Treatment of animal tumors with tumor-specific monoclonal antibody-hematoporphyrin conjugates","volume":"130","author":"Mew D","year":"1983","unstructured":"D Mew, CK Wat, GH Towers, JG Levy, Photoimmunotherapy: Treatment of animal tumors with tumor-specific monoclonal antibody-hematoporphyrin conjugates. J Immunol 130, 1473\u20131477 (1983).","journal-title":"J Immunol"},{"key":"e_1_3_3_19_2","first-page":"4762","article-title":"Photoimmunotherapy of human ovarian carcinoma cells ex vivo","volume":"51","author":"Goff BA","year":"1991","unstructured":"BA Goff, M Bamberg, T Hasan, Photoimmunotherapy of human ovarian carcinoma cells ex vivo. Cancer Res 51, 4762\u20134767 (1991).","journal-title":"Cancer Res"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.18.1557"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5705"},{"key":"e_1_3_3_22_2","first-page":"4490","article-title":"Epidermal growth factor receptor-targeted immunophotodiagnosis and photoimmunotherapy of oral precancer in vivo","volume":"61","author":"Soukos NS","year":"2001","unstructured":"NS Soukos, et al., Epidermal growth factor receptor-targeted immunophotodiagnosis and photoimmunotherapy of oral precancer in vivo. Cancer Res 61, 4490\u20134496 (2001).","journal-title":"Cancer Res"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.201200016"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.09.003"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2554"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21093"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1625"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1854"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc100584d"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961127)68:5<588::AID-IJC6>3.0.CO;2-V"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602447"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605436"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1436"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.504"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2003)077<0431:TCTOTE>2.0.CO;2"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.01.014"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1902"},{"key":"e_1_3_3_38_2","first-page":"493","article-title":"Intraperitoneal photodynamic therapy","volume":"134","author":"Cengel KA","year":"2007","unstructured":"KA Cengel, E Glatstein, SM Hahn, Intraperitoneal photodynamic therapy. Cancer Treat Res 134, 493\u2013514 (2007).","journal-title":"Cancer Treat Res"},{"key":"e_1_3_3_39_2","first-page":"1075","article-title":"Intraperitoneal photodynamic therapy of human epithelial ovarian carcinomatosis in a xenograft murine model","volume":"56","author":"Molpus KL","year":"1996","unstructured":"KL Molpus, et al., Intraperitoneal photodynamic therapy of human epithelial ovarian carcinomatosis in a xenograft murine model. Cancer Res 56, 1075\u20131082 (1996).","journal-title":"Cancer Res"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.516"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1949"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/7933"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc200169x"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2986"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19960101)60:1<23::AID-JCB5>3.0.CO;2-5"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth820"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600958"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/443765a"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1692"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1440"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913679107"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.09310"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-12-0221"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.2.021104"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.05.023"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204082"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1319493111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T16:14:58Z","timestamp":1689005698000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1319493111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,26]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,3,11]]}},"alternative-id":["10.1073\/pnas.1319493111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1319493111","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,26]]},"assertion":[{"value":"2014-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}