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These findings establish NFATc1 as a key transcriptional repressor of cartilage breakdown and OA. Additionally, these findings provide a unique model of OA that is an attractive platform for the preclinical development of treatments to alter the course of OA.<\/jats:p>","DOI":"10.1073\/pnas.1320036110","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T23:49:39Z","timestamp":1384818579000},"page":"19914-19919","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":72,"title":["NFATc1 and NFATc2 repress spontaneous osteoarthritis"],"prefix":"10.1073","volume":"110","author":[{"given":"Matthew B.","family":"Greenblatt","sequence":"first","affiliation":[{"name":"Department of Pathology, Division of Rheumatology, Allergy and Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Y.","family":"Ritter","sequence":"additional","affiliation":[{"name":"Department of Medicine, 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